Sibling Comparisons to Account for Confounding in Observational Studies

JAMA 2026

View at publisher
Authors: Viktor H. Ahlqvist, Brian Lee, Yu-Han Chiu
DOI: 10.1001/jama.2025.22234
Cited by: 11
References: 9

Abstract

This JAMA Guide to Statistics and Methods explains how sibling analysis can be used to account for confounding in observational studies, using the example of a study on acid suppressants during pregnancy and risk of neuropsychiatric disorders in offspring.

Fields of Study & Subjects

Prenatal Substance Exposure Effects Advanced Causal Inference Techniques Neonatal and fetal brain pathology

Publication details

Journal / source
JAMA
Publisher
American Medical Association (AMA)
Volume
335
Issue
7
Pages
626–626
Publication date
7 January 2026
Language
EN