Intravenous Tenecteplase Prior to Endovascular Treatment for Ischemic Stroke at 4.5 to 24 Hours

JAMA 2026 Open access

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Authors: Yunyun Xiong, F Y, Hao Wang, Manjun Hao, Thanh N. Nguyen, Marc Fisher, Aoming Jin, Zhu Cao, Ziran Wang, Xiaoxi Yao, Ganghua Feng, Xu Y
+64 more Shifeng Guo, Hao Qin, Xianjun Huang, Jianxin Xu, Z J Chen, Jinglin Yuan, Wenshuai Li, Wei Hu, Xueyan Feng, Lixia Zong, Wanxing Ye, Chunmiao Duan, Liyuan Wang, Shuangzhe Wu, Bruce C. V. Campbell, Yongjun Wang, TNK-PLUS Investigators, Chaosheng Li, Haihua Yang, Fanping Kong, Haijun Qiu, Chuyuan Ni, Honggang Wang, Huakun Liu, Jianfeng Chu, Feng Xie, Hongguo Dai, Sujing Zhuang, Ying Liu, Mingchao Ding, Qinglin Dong, Yanxin Wang, Shujun Gao, Sihua Liu, Yutie Zhao, Haicheng Yuan, Cai Zhang, Dongcheng Xu, Lei Mu, Jun Li, Guang Zhang, Huaizhang Shi, Zhenyu Kong, Hongyu Qiao, Min Guan, Jia Yu, Wei Wu, Xiaosong Li, Lihua Wang, Haitao Wang, Bin Zhang, Lei Yang, Liguo Chang, Jiajun Zhuang, Li Zhou, Honghao Man, Xinmin Fu, Shunyuan Guo, Zongjie Shi, Magdy H Selim, Ding Ding, Wenjie Cao, Xiaoquan Xu, Ziqi Xu
DOI: 10.1001/jama.2026.4292
Cited by: 3
References: 35

Abstract

Importance: Whether intravenous tenecteplase prior to endovascular treatment (EVT) for ischemic stroke reduces disability in the late time window is unclear. Objective: To investigate the adverse events and efficacy of tenecteplase prior to EVT in patients 4.5 to 24 hours after ischemic stroke onset due to proximal middle cerebral artery (MCA) occlusion. Design, Setting, and Participants: Multicenter, phase 3, randomized, open-label, blinded end point, superiority trial conducted at 40 centers in China. Adult (≥18 years) patients with acute ischemic stroke 4.5 to 24 hours after last known to be well due to MCA-M1 or proximal M2 occlusion with salvageable brain tissue (ischemic core volume

Fields of Study & Subjects

Acute Ischemic Stroke Management Stroke Rehabilitation and Recovery Intracerebral and Subarachnoid Hemorrhage Research

Publication details

Journal / source
JAMA
Publisher
American Medical Association (AMA)
Volume
335
Issue
21
Pages
1849–1849
Publication date
8 May 2026
Language
EN