The CRT-Estimands Framework for Cluster Randomized Trials

JAMA 2026

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Authors: Brennan C Kahan, Gary S. Collins, Frank Bretz, Fan Li
DOI: 10.1001/jama.2026.8368
Cited by: 1
References: 4

Abstract

This Viewpoint discusses some specific challenges in defining estimands for cluster randomized trials and illustrates how the CRT-Estimands Framework can be applied to improve the interpretation of trial results.

Fields of Study & Subjects

Meta-analysis and systematic reviews Statistical Methods and Bayesian Inference Advanced Causal Inference Techniques

Publication details

Journal / source
JAMA
Publisher
American Medical Association (AMA)
Volume
336
Issue
2
Pages
101–101
Publication date
21 May 2026
Language
EN