The Global Clinical Trial Landscape for Children and Adolescents With Cancer

JAMA Network Open 2026 Open access

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Authors: Margit Mikkelsen, Linh T. D. Pham, Catrian Sotelo, Mackenzie Kelley, Michael S. B. Edwards, Ryan R Lion, Hanna Ravi, Guillermo Chantada, John T. Lucas, Giles Robinson, Victor M. Santana, Meenakshi Devidas
+2 more Rodriguez-Galindo Carlos, Daniel C. Moreira
DOI: 10.1001/jamanetworkopen.2025.52510
Cited by: 8
References: 20

Abstract

Importance: The improvement of childhood cancer outcomes has relied on clinical trials, primarily from high-income countries (HICs). Inconsistent access to clinical trials, especially in low-income countries (LICs) and middle-income countries, contributes to disparate care and limits the generalizability of conclusions from trials conducted in HICs. Objective: To describe the global availability of clinical trials for children and adolescents with cancer in different economic settings. Design, Setting, and Participants: In this cross-sectional study, the World Health Organization's International Clinical Trials Registry Platform was used to search for clinical trials on May 8, 2024. Trials were included if they were interventional studies for pediatric patients (

Fields of Study & Subjects

Childhood Cancer Survivors' Quality of Life Acute Lymphoblastic Leukemia research Pharmaceutical studies and practices

Publication details

Journal / source
JAMA Network Open
Publisher
American Medical Association (AMA)
Volume
9
Issue
1
Pages
e2552510–e2552510
Publication date
6 January 2026
Language
EN