Cerebral Oximetry–Guided Treatment and Cerebral Oxygenation in Extremely Preterm Infants

JAMA Network Open 2026 Open access

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Authors: Pranav R. Jani, Traci-Anne Goyen, Kiran Kumar Balegar, Rajesh A Maheshwari, Maria Saito-Benz, Tim Schindler, James Moore, Manelle Merhi, Melinda Cruz, Yang Song, Hayley McDonagh, Melissa Luig
+18 more Mark Brian Tracy, Daphne D’Çruz, Aldo Perdomo, Stephanie Morakeas, Vishnu Dasireddy, Mihaela Culcer, Vijay Shingde, Karen Bennington, J Michałowski, Andreja Fucek, Jennifer Querim, Sean M. Stevens, James Santanelli, James Elhindi, Brian Gloss, Robert J Halliday, Dharmesh M Shah, Himanshu Popat
DOI: 10.1001/jamanetworkopen.2025.57620
Cited by: 1
References: 21

Abstract

Importance: Preterm infants are at high risk of developing brain injury, and near-infrared spectroscopy (NIRS) offers the ability to measure cerebral oxygenation. The impact of using a standardized treatment guideline combined with a single NIRS device manufacturer (Nonin Medical Inc) and neonatal sensor on cerebral oxygenation has not been previously examined. Objective: To investigate whether cerebral oximetry with a dedicated treatment guideline improves cerebral oxygenation stability. Design, Setting, and Participants: This was a single-blinded, 2-arm randomized clinical trial conducted from October 2021 to July 2024 at 5 tertiary neonatal intensive care units across Australia, New Zealand, and the US. Infants born at less than 29 weeks' gestation and aged younger than 6 hours underwent 1:1 random allocation stratified by gestational age (

Fields of Study & Subjects

Optical Imaging and Spectroscopy Techniques Neonatal Respiratory Health Research Neonatal and fetal brain pathology

Publication details

Journal / source
JAMA Network Open
Publisher
American Medical Association (AMA)
Volume
9
Issue
2
Pages
e2557620–e2557620
Publication date
5 February 2026
Language
EN