Maternal Body Mass Index, Gestational Weight Gain, and Cardiovascular Disease in Offspring
Abstract
Importance: The long-term association of maternal body mass index (BMI) in early pregnancy and gestational weight gain (GWG) with offspring cardiovascular disease (CVD) risk remains unclear. Objective: To analyze the associations of maternal BMI and GWG with offspring CVD risk. Design, Setting, and Participants: This cohort study used data from national registers in Sweden for individuals born from January 1, 1982, to December 31, 2014. Participants were followed up from birth until the first diagnosis of CVD, death, emigration from Sweden, or December 31, 2023, whichever came first. Data were analyzed from February 1, 2025, to June 16, 2026. Exposures: Data were obtained on maternal BMI in early pregnancy and GWG from the Swedish Medical Birth Register. BMI was categorized as underweight (
Fields of Study & Subjects
Gestational Diabetes Research and Management
Birth
Development
and Health
Pregnancy and preeclampsia studies
Publication details
- Journal / source
- JAMA Network Open
- Publisher
- American Medical Association (AMA)
- Volume
- 9
- Issue
- 9
- Pages
- e2631324–e2631324
- Publication date
- 1 September 2026
- Language
- EN