Lifelong Genetic Inhibition of PCSK9 and Hepatic Safety

JAMA Network Open 2026 Open access

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Authors: Alessia Di Costanzo, Ilaria Pirona, Laura D’Erasmo, Silvia Buonaiuto, Vincenza Colonna, Allegra Via, Daniele Tramontano, Carlo Maiorca, Marcello Arca
DOI: 10.1001/jamanetworkopen.2026.32994
Cited by: 1
References: 10

Abstract

This genetic association study investigates whether the full spectrum of rare PCSK9 loss-of-function variants is associated with incident liver-related outcomes, given the development of therapies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9).

Fields of Study & Subjects

Lipoproteins and Cardiovascular Health Alzheimer's disease research and treatments Protease and Inhibitor Mechanisms

Publication details

Journal / source
JAMA Network Open
Publisher
American Medical Association (AMA)
Volume
9
Issue
9
Pages
e2632994–e2632994
Publication date
10 September 2026
Language
EN