Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome

JAMA Neurology 2026 Open access

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Authors: Jason K Russell, Zinayida Schlachetzki, Beau M. Ances, Michael S. Rafii, Beau M. Ances, Howard F Andrews, Karen Bell, Rasmus M. Birn, Adam M Brickman, Peter Bulova, J M Burns, Amrita K. Cheema
+46 more Kewei W. Chen, Bradley T Christian, Isabel C. H. Clare, Ann D Cohen, Eric W Doran, Tatiana M Foroud, Benjamin L. Handen, J Harp, Sigan L Hartley, Elizabeth Head, Denise Head, Christy L. Hom, Lawrence Honig, Miloš D. Ikonomović, Sterling C Johnson, M. Ilyas Kamboh, David Keator, Julia Kofler, William Charles Kreisl, Sharon J Krinsky-McHale, Florence Y. Lai, Patrick Lao, Charles M. Laymon, Joseph Hyungwoo Lee, Ira T Lott, Victoria C. Lupson, Mark Mapstone, Davneet Singh Minhas, Neelesh Nadkarni, Sid O'Bryant, Deborah I. Pang, Melissa J. Peterson, Julie C Price, Lauren Ptomey, Margaret Pulsifer, Michael S. Rafii, Herminia Diana Rosas, Frederick Schmitt, Nicole Schupf, Wayne P. Silverman, Dana L Tudorascu, Rameshwari Tumuluru, Badri Varadarajan, Michael A. Yassa, Shahid Zaman, Fan Zhang
DOI: 10.1001/jamaneurol.2025.5261
Cited by: 1
References: 6

Abstract

This cross-sectional study examines data for participants in the Alzheimer Biomarker Consortium–Down Syndrome study to gauge the concordance of clinical and biological Alzheimer disease staging.

Fields of Study & Subjects

Down syndrome and intellectual disability research Dementia and Cognitive Impairment Research Genetic Neurodegenerative Diseases

Publication details

Journal / source
JAMA Neurology
Publisher
American Medical Association (AMA)
Volume
83
Issue
3
Pages
294–294
Publication date
12 January 2026
Language
EN