Alzheimer Disease–Relevant Biomarker Elevations in Psychosis and Broad Neuropsychiatric Impairment

JAMA Psychiatry 2026 Open access

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Authors: Michael J. C. Bray, Jacob S. Shaw, Christopher B. Morrow, Chiadi U. Onyike, Alzheimer’s Disease Neuroimaging Initiative, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, Susan Landau, Monica Rivera-Mindt
+88 more Ozioma Okonkwo, Leslie M. Shaw, Edward B. Lee, Arthur W. Toga, Laurel Beckett, Danielle Harvey, Robert C. Green, Andrew J. Saykin, Kwangslk Nho, Richard J. Perrin, Duygu Tosun, Pallavi Sachdev, Erin Drake, Tom Montine, Cat Conti, Rachel Nosheny, Diana Truran Sacrey, Juliet Fockler, Melanie Jayne Miller, Winnie Kwang, Chengshi Jin, Adam Diaz, Miriam Thiel Ashford, Derek Flenniken, Adrienne Kormos, Michael S. Rafii, REMA RAMAN, Gustavo Jimenez, Michael Donohue, Jennifer Salazar, Andrea Fidell, Virginia Boatwright, Justin Robison, Caileigh Zimmerman, Yuliana Cabrera, Sarah Walter, Taylor Clanton, Elizabeth Shaffer, Caitlin Webb, Lindsey Hergesheimer, Stephanie Smith, Sheila Ogwang, Olusegun Adegoke, Payam Mahboubi, Jeremy Pizzola, Cecily W. Jenkins, Naomi Saito, Kedir Adem Hussen, Hannatu Amaza, Mai Seng Thao, Shaniya Parkins, Ombolanle Ayo, Matt Glittenberg, Kaori Kubo Germano, Joe Strong, Trinity Weisensel, Fabiola Magana, Lisa A. Thomas, Vanessa Katherin Erazo Guzmán, Adeyinka Ajayi, Joseph Di Benedetto, Sandra Talavera, Clifford R. Jack, Felmlee JP, Nick C. Fox, Paul Thompson, Charles DeCarli, Arvin Forghanian-Arani, Brett Borowski, Calvin Reyes, Catie Hedberg, Chad Ward, Christopher Schwarz, Denise Alexandra Chavez Reyes, Jeff Gunter, John Moore-Weiss, Kejal Kantarci, Leonard C. Matoush, Matthew L. Senjem, Prashanthi Vemuri, Robert Reid, Ian B. Malone, Sophia I. Thomopoulos, Talia M. Nir, Neda Jahanshad, Alexander Knaack, Evan Fletcher, Duygu Tosun-Turgut
DOI: 10.1001/jamapsychiatry.2025.4347
Cited by: 1
References: 6

Abstract

This cohort study examines the association of serum hyperphosphorylated tau and neurofilament light chain concentrations with psychosis in Alzheimer disease.

Fields of Study & Subjects

Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research Schizophrenia research and treatment

Publication details

Journal / source
JAMA Psychiatry
Publisher
American Medical Association (AMA)
Volume
83
Issue
3
Pages
318–318
Publication date
21 January 2026
Language
EN