Tenecteplase versus alteplase for acute ischemic stroke

Cochrane Database of Systematic Reviews 2026 Open access

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Authors: Hemanshu Prabhakar, Indu Kapoor, Charu Mahajan, Chandini Kukanti, M. Kalaivani
DOI: 10.1002/14651858.cd016325
Cited by: 1
References: 30

Abstract

OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To assess the benefits and harms of tenecteplase compared to alteplase in people suffering from large vessel occlusion or non-large vessel occlusion acute ischemic stroke. Secondary objective To explore the effects of the interventions (tenecteplase and alteplase) in different groups based on age, sex, ethnicity, and place of residence (high-, middle-, low-income country), to inform health equity considerations.

Fields of Study & Subjects

Acute Ischemic Stroke Management Dementia and Cognitive Impairment Research Stroke Rehabilitation and Recovery

Publication details

Journal / source
Cochrane Database of Systematic Reviews
Publisher
Wiley
Volume
2026
Issue
1
Pages
CD016325–CD016325
Publication date
29 January 2026
Language
EN