Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood & Cancer 2026 Open access

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Authors: Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar V. Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter Meade Anderson, Matteo M. Trucco, Zachary D. C. Burke, Lukas M. Nystrom, Nathan W. Mesko
+2 more A. Magnelli, Erin Sennett Murphy
DOI: 10.1002/1545-5017.70087
Cited by: 0
References: 35

Abstract

BACKGROUND/OBJECTIVES: Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT. DESIGN/METHODS: We reviewed cases of recurrent/metastatic osteosarcoma treated with SBRT from 2015 to 2023. Outcomes included local control, overall survival (OS), and toxicity. Local failures (LFs) were categorized as in-field (≥80% of recurrence within the 95% isodose line), marginal (20%-80%), or out-of-field (

Fields of Study & Subjects

Sarcoma Diagnosis and Treatment Advanced Radiotherapy Techniques Management of metastatic bone disease

Publication details

Journal / source
Pediatric Blood & Cancer
Volume
73
Issue
3
Pages
e70087–e70087
Publication date
14 January 2026
Language
EN