IPMK at the crossroads of cellular signaling in health and disease

FEBS Letters 2026 Open access

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Authors: Sera Kim, Sera Kim, Jaeseung Ryu, Jae Yeong Park, Ji Kwang Kim, Lauren S. Whang, Seyun Kim, Seyun Kim
DOI: 10.1002/1873-3468.70256
Cited by: 0
References: 90

Abstract

Inositol phosphates (InsPs) represent a conserved class of water-soluble signaling molecules found in all eukaryotes. Their biosynthesis involves a tightly regulated enzymatic network, with inositol polyphosphate multikinase (IPMK) functioning as a pivotal catalytic hub. IPMK exhibits broad substrate specificity, phosphorylating various InsPs and phosphatidylinositol 4,5-bisphosphate. Beyond its enzymatic activity, IPMK also modulates key signaling pathways through noncatalytic mechanisms, including direct interactions with protein partners. This review highlights the functional attributes of IPMK, its diverse roles in cellular physiology and disease, and outlines current challenges and future directions in IPMK research.

Fields of Study & Subjects

Protein Kinase Regulation and GTPase Signaling Phytase and its Applications Coagulation Bradykinin Polyphosphates and Angioedema

Publication details

Journal / source
FEBS Letters
Volume
600
Issue
17
Pages
2361–2378
Publication date
6 January 2026
Language
EN