Investigating human pregnancy with trophoblast organoids
Abstract
The placenta plays a vital role in supporting and nourishing the fetus throughout pregnancy, yet the mechanisms governing its development remain poorly understood. Recent advances in 3D human trophoblast organoid systems derived from both primary tissues and stem cells provide physiologically relevant platforms to investigate placental development in both health and disease. This 'In a Nutshell' review highlights how these models are transforming our ability to investigate human placental biology in pregnancy.
Fields of Study & Subjects
Pregnancy and preeclampsia studies
Gestational Trophoblastic Disease Studies
Maternal and fetal healthcare
Publication details
- Journal / source
- FEBS Letters
- Publisher
- Wiley
- Publication date
- 24 April 2026
- Language
- EN