Toxins of Clostridioides difficile
Abstract
Clostridioides difficile infection (CDI) affects not only humans but also animals. The pathogen produces two major exotoxins, toxin A (TcdA) and toxin B (TcdB), which are key drivers of diseases in humans such as antibiotic-associated diarrhea and pseudomembranous colitis. Certain strains additionally produce a binary toxin termed CDT ( C. difficile transferase). This chapter outlines the structure, cellular uptake, and molecular mechanisms of C. difficile toxins and discusses current anti-toxin strategies designed to counteract their harmful effects.
Fields of Study & Subjects
Clostridium difficile and Clostridium perfringens research
Toxin Mechanisms and Immunotoxins
Escherichia coli research studies
Publication details
- Journal / source
- Wiley eBooks
- Pages
- 83–94
- Publication date
- 3 March 2026
- Language
- EN
- Document type
- Book chapter