Index

a Abdominal aortic aneurysm (AAA) 373 prevalence and rupture risk 373 screening and surgical prevention 372-373 Acute coronary syndrome (ACS) 283, 285, 289-299, 391, 394, 395, 400, 403, 407, 409, 410 biomarkers in early diagnosis 283, 289-290 MINOCA and nonobstructive disease 394 plaque rupture and erosion 283 sex-related differences in diagnosis and outcomes 391-392 STEMI vs NSTEMI 283 ADAMs/ADAMTS 218, 221 ECM remodeling enzymes 218 Adenosine diphosphate (ADP) 110-111, 121 as platelet agonist 121 Adhesive glycoproteins 217-218 laminins and cell polarity 218 tenascins 218, 226, 230 Adrenergic receptors (β1, β2) 525-529 Affinity-based proteomics 488, 491, 493, 498-499, 507-508, 510.See also Targeted proteomics antibody-based methods 35 aptamers and SOMAmers 40-41 comparison with mass spectrometry-based methods 499 O-link proximity extension assays 491, 499, 502, 503, 508, 509 PEA technology (Olink) 38-40 SomaScan aptamer-based assays 491, 499, 502, 503 Aggrecan 217, 227 Albumin.See also Human serum albumin (HSA) oxidative modifications 88-98 structure and functions 79-80 Albuminuria 84-88 Aldosterone 349 cardiac fibrosis and remodeling 347 genomic and non-genomic effects 349 Analyzers (mass analyzers) 9 Fourier transform-ion cyclotron resonance (FT-ICR) 12-13 ion traps 11-14 Orbitrap 13-14 quadrupole filters 10-11 time-of-flight (ToF) 9-10 Angiotensin II (Ang-II) 347-349 counter-regulatory axis (Ang-(1-7)) 349 RAAS signaling and vascular remodeling 347 Antibody arrays 41 Antioxidant properties 84 Anxiety, stress and depression 391, 413-416 impact on cardiovascular risk 391, 395, 407 psychosocial risk factors in women 415 Aortic aneurysm 227, 231 ECM dysregulation 227 Aortic arch and ascending aorta 373-374 branches and hemodynamics 374 Windkessel function 373 Aortic dissection 374-375 epidemiology and incidence 372-373 familial thoracic aortic aneurysm and dissection (FTAAD) 375 screening and biomarkers 372 Cardiovascular Proteomics Techniques: Applications for Clinical and Laboratory Research, First Edition.Edited by Cristina Banfi.