Conditional sparing in FLASH radiotherapy: Conformal dosimetry and ALARA remain essential

Journal of Applied Clinical Medical Physics 2026 Open access

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Authors: Chih‐Chiang Chang, Yangguang Ma, Minglei Kang, Paliwal Br, Zachary Morris, Benjamin Durkee, Chingyun Cheng
DOI: 10.1002/acm2.70664
Cited by: 1
References: 57

Abstract

FLASH radiotherapy shows promise in reducing normal tissue toxicity while maintaining tumor control. However, preclinical and early clinical evidence reveal biological and technical uncertainties. We review preclinical and veterinary studies, highlight unexpected toxicities, and argue that the fundamental principles of precision and safety in radiotherapy-particularly conformal treatment and ALARA-remain crucial.

Fields of Study & Subjects

Advanced Radiotherapy Techniques Radiation Therapy and Dosimetry Hepatocellular Carcinoma Treatment and Prognosis

Publication details

Journal / source
Journal of Applied Clinical Medical Physics
Publisher
Wiley
Volume
27
Issue
7
Pages
e70664–e70664
Publication date
23 June 2026
Language
EN