Meningovascular Inflammation in Cerebral Amyloid Angiopathy‐Related Cortical Superficial Siderosis

Annals of Clinical and Translational Neurology 2026 Open access

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Authors: Philipp Arndt, Eya Khadhraoui, Sebastian Johannes Müller, Katja Neumann, Hendrik Mattern, S. Meuth, Valentina Perosa, Andreas Charidimou, S Schreiber
DOI: 10.1002/acn3.70315
Cited by: 1
References: 22

Abstract

The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post-contrast vessel wall MRI (VWI) and CSF analysis. Although only 27% met current CAA-ri criteria, 93% showed vessel wall enhancement or sulcal hyperintensities near cSS, frequently extending beyond. Seven patients with follow-up VWI demonstrated corticosteroid-responsive regression of inflammation. CSF albumin quotients, indicating blood-brain barrier dysfunction, correlated with MRI inflammation scores. These findings reveal subclinical meningovascular inflammation in cSS and support VWI for detecting a broader CAA-related inflammation spectrum.

Fields of Study & Subjects

Intracerebral and Subarachnoid Hemorrhage Research Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments

Publication details

Journal / source
Annals of Clinical and Translational Neurology
Publisher
Wiley
Volume
13
Issue
5
Pages
1052–1059
Publication date
14 January 2026
Language
EN