Early Recognition of Treatment‐Responsive Rapidly Progressive Dementia: The Modified STAM3 m P Score

Annals of Clinical and Translational Neurology 2026 Open access

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Authors: R. W. van Steenhoven, N. Satyadev, A. E. M. Bastiaansen, Y. D. Piura, J. Kerstens, Y. S. Crijnen, J. Brenner, T. Brand, T. M. Bienfait, S. Veenbergen, J. M. de Vries, F A de Jong
+5 more E.G.P. Dopper, P.A.E. Sillevis Smitt, H. Seelaar, G. S. Day, M. J. Titulaer
DOI: 10.1002/acn3.70434
Cited by: 1
References: 20

Abstract

ABSTRACT Early identification of patients with treatment‐responsive rapidly progressive dementia (RPD) is important as early treatment improves outcomes. The STAM 3 P score identifies treatment‐responsive RPD using “high risk” presenting features. We optimized performance by adding a time component (i.e., dementia within 3 months) and validated the modified “STAM3 m P score” in two independent cohorts ( n = 302). A STAM3 m P score ≥ 1 identified 96% of patients with treatment‐responsive RPD; ≥ 3 features were highly specific (98%). These data suggest that ≥ 1 STAM3 m P features effectively identifies treatment‐responsive RPD and may be used to prioritize investigations, whereas ≥ 3 STAM3 m P features are highly specific and may inform early treatment decisions.

Fields of Study & Subjects

Dementia and Cognitive Impairment Research Intensive Care Unit Cognitive Disorders Alzheimer's disease research and treatments

Publication details

Journal / source
Annals of Clinical and Translational Neurology
Publisher
Wiley
Volume
13
Issue
9
Pages
1956–1960
Publication date
27 May 2026
Language
EN