“Molecular Lock”‐Anchored Elastomer Coating with Robust Interfacial Bonding for Anti‐Adhesive Nasal Stents

ABSTRACT Anti‐adhesive coatings are increasingly demanded in nasal stents to minimize secondary tissue damage and pain upon removal. However, conventional coatings are often limited by weak interfacial bonding, poor environmental stability, or insufficient biocompatibility. Here, we report a biocompatible anti‐adhesive elastomer coating based on a chain entanglement model, in which polymer loops grafted onto the substrate serve as “molecular locks” to anchor a silicone oil‐impregnated polydimethylsiloxane (PDMS) network via ultrasound‐induced chain interpenetration. Free of toxic catalysts, fluorinated compounds, or intricate crosslinking systems, this “molecular lock”‐anchored elastomer coating achieves superior anti‐adhesive performance against common daily liquids, a range of biofluids (e.g., blood, mucus, saliva, tears), and blood scabs. It is applicable across a broad range of substrates, including metals, ceramics, and polymers, exhibiting MPa‐level interfacial strength and ultralow droplet retention forces (≈0.3 µN). Notably, it remains stable under harsh environmental conditions, such as solvent immersion, tape peeling, heating, ultrasonication, and scratching. In a rabbit nasal septum hemostasis model, the stent with “molecular lock”‐anchored elastomer coating effectively resisted blood adhesion and accelerated mucosal wound healing, offering a promising platform for next‐generation biofriendly implantable device coatings.