Ion‐in‐Conjugation‐Enabled Remineralized Scaffold for Spatiotemporal Control of Infection and Bone Regeneration (Adv. Funct. Mater. 13/2026)

Advanced Functional Materials 2026 Open access

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Authors: Jiaxu Shi, Weicheng Chen, Xiaopeng Zhao, Dachuan Liu, K. -Y. Lu, Yan Xu, Tingting Xia, Zhangqin Yuan, Jun He, Bin Li, Song Chen
DOI: 10.1002/adfm.74188
Cited by: 0

Abstract

Bone Regeneration In their Research Article (10.1002/adfm.202517239), Zhangqin Yuan, Jinghui He, Bin Li, Song Chen, and co-workers utilize a mineralization strategy and in situ synthesis of ion-conjugated polymers (IIC) to prepare a scaffold, achieving sequential regulation of infection control and bone regeneration. The IIC coating releases antibacterial ions (Zn2+/Ni2+), exhibiting excellent antibacterial properties by inhibiting protein synthesis and DNA replication. Meanwhile, the mineral layer releases Sr2+ that promotes bone regeneration through the PI3K-Akt signaling pathway.

Fields of Study & Subjects

Bone Tissue Engineering Materials Orthopedic Infections and Treatments Antimicrobial agents and applications

Publication details

Journal / source
Advanced Functional Materials
Volume
36
Issue
13
Publication date
1 February 2026
Language
EN