Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis (Adv. Healthcare Mater. 2/2026)

Advanced Healthcare Materials 2026

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Authors: Juyeon Kim, Sung Sik Hur, Jae Hong Park, Myung Jin Ban, Jin‐Young Kim, Joo Hyun Kim, Ji Hyae Choo, Hae‐Won Kim, Ju Hun Lee, Man Ryul Lee, Yongsung Hwang
DOI: 10.1002/adhm.70550
Cited by: 0

Abstract

Mechanobiology This cover illustrates stiffness-dependent cell surface thiol engineering using TCEP, which reduces disulfide bonds to expose free –SH groups. The thiol-modified cells exhibit enhanced focal adhesion, cytoskeletal remodeling, and intracellular tension, promoting myogenic differentiation and myotube maturation via the FAK–PI3K–AKT axis. This approach highlights how redox modulation strengthens mechanotransduction to advance skeletal muscle regeneration. More details can be found in the Research Article by Ju Hun Lee, Man Ryul Lee, Yongsung Hwang, and co-workers (DOI: 10.1002/adhm.202500914).

Fields of Study & Subjects

Muscle Physiology and Disorders Cellular Mechanics and Interactions Tissue Engineering and Regenerative Medicine

Publication details

Journal / source
Advanced Healthcare Materials
Volume
15
Issue
2
Publication date
1 January 2026
Language
EN