A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening (Adv. Healthcare Mater. 7/2026)

Advanced Healthcare Materials 2026 Open access

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Authors: Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki
+9 more Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori
DOI: 10.1002/adhm.70672
Cited by: 0

Abstract

Drug Screening The cover image illustrates patient-derived human kidney tubuloids that model chronic kidney disease through repeated cisplatin treatment, recapitulating cellular senescence, senescence-associated secretory phenotype (SASP), and fibrosis as a platform for drug discovery research. More details can be found in the Research Article by Yutaro Mori and co-workers (DOI: 10.1002/adhm.202501795).

Fields of Study & Subjects

Chemotherapy-induced organ toxicity mitigation Acute Kidney Injury Research Telomeres Telomerase and Senescence

Publication details

Journal / source
Advanced Healthcare Materials
Volume
15
Issue
7
Publication date
1 February 2026
Language
EN