Correction to “Granular Biomaterials as Bioactive Sponges for the Sequestration and Release of Signaling Molecules”

D. B. Emiroglu, A. Singh, B. Marco-Dufort, N. Speck, P. G. Rivano, J. S. Oakey, N. Nakatsuka, A. J. deMello, C. Labouesse, and M. W. Tibbitt “Granular Biomaterials as Bioactive Sponges for the Sequestration and Release of Signaling Molecules” Advanced Healthcare Materials 13, no. 25 (2024): 202400800, https://doi.org/10.1002/adhm.202400800. In Figure 2f, all data points were correctly positioned; however, the colors indicating granular 5 wt.% and granular 10 wt.% for Rhodamine B and FITC-BSA were swapped. These have been corrected such that 5 wt.% granular hydrogel samples have lighter symbols, and 10 wt.% granular hydrogel samples have darker symbols. Similarly, we have changed the shades of the diamonds in Figure 2e in order to avoid confusion and stay consistent with the color coding of 5 wt.% granular hydrogels in the rest of the figure. The figure caption for Figure 2e has also been corrected, where we removed the mention of 10 wt.% granular hydrogels, as these were not used in this panel. With these additions, the colors and shading are now consistent for all datasets, and the corrected Figure 2 is appended below. We apologize for this error. Figure 2 Biomolecule diffusion in granular hydrogels. Transport of model biomolecules into bulk and granular hydrogels (8-arm PEG-NB/DTT, 5–10 wt.%; pH 7.4, 25°C; 45 µL) is facilitated by the presence of interconnected porosity. Diffusion assays for (a) Rhodamine B (Rh-B; 1 mg mL−1; 45 µL). (b) Lysozyme (2 mg mL−1; 45 µL) and (c) Fluorescein isothiocyanate-labeled bovine serum albumin (FITC-BSA; 1 mg mL−1; 45 µL) were performed to study the transport profile of model biomolecules. Supernatant concentrations were assessed via absorbance measurements. A transport model was developed to provide a theoretical framework that explains the transport of model biomolecules into hydrogels. (d) Schematic representation of the concentration profiles of supernatant, CS, and hydrogel, CH , across an interface, separated by a hypothetical film of thickness, l. Mass transport coefficients, k, were extracted using the derived analytical model by fitting experimental diffusion curves for each biomolecule. According to our hypothesis, by accounting for the increased surface area available for diffusion, we can appropriately represent the diffusion in granular hydrogels. (e) Apparent k for bulk and granular hydrogels with the same composition (8-arm PEG-NB/DTT, 5 wt.%; pH 7.4, 25°C). (f) Area corrected k for granular hydrogels (8-arm PEG-NB/DTT, 5–10 wt.%; pH 7.4, 25°C. The results are consistent with standard diffusion theories, which state that the transport rate is proportional to network mesh size and inversely proportional to biomolecule size. Data are represented as mean +/− std., n = 3.