High Concentration Antibody Formulations Enabled via Thermostable Ionic Liquids

Advanced Materials 2026 Open access

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Authors: Metecan Erdi, Anujan Ramesh, Vinny Chandran Suja, S. Zhang, Samir Mitragotri, Bijay Singh
DOI: 10.1002/adma.202511918
Cited by: 5
References: 40

Abstract

Concentrated protein formulations have garnered significant attention in both commercial and research domains due to their relevance in patient-favored, subcutaneous administration. However, these formulations face challenges such as high viscosity and elevated potential for aggregation, primarily driven by intermolecular electrostatic and hydrophobic protein-protein interactions (PPIs). Achieving an acceptable injectability profile (

Fields of Study & Subjects

Ionic liquids properties and applications Advanced Drug Delivery Systems Advanced Biosensing Techniques and Applications

Publication details

Journal / source
Advanced Materials
Publisher
Wiley
Volume
38
Issue
14
Pages
e11918–e11918
Publication date
4 February 2026
Language
EN