Enhanced Biofilm Infiltration by Drug‐laden Coacervate for Treating Refractory Infections

Advanced Materials 2026

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Authors: Ruinan Wang, H. Y. Li, Bo Yi, Sirong Chen, Qiangjun Ling, Tianshen Jiang, Hao Fu, Xuefeng Yang, Pengchao Zhao, Liming Bian
DOI: 10.1002/adma.202521500
Cited by: 5
References: 55

Abstract

ABSTRACT The effective treatments of biofilm‐related refractory infections such as osteomyelitis are hampered by the limited drug coverage to large infected areas and infiltration into the biofilm at infection sites. Herein, guided by the hypothesis that liquid water‐immiscible coacervates with ultra‐low interfacial tension could effectively infiltrate these barriers, it is systematically screened 7 representative coacervates for their biofilm infiltration performance. Coacervates with ultra‐low interfacial tension (

Fields of Study & Subjects

Polymer Surface Interaction Studies Orthopedic Infections and Treatments Bacterial biofilms and quorum sensing

Publication details

Journal / source
Advanced Materials
Publisher
Wiley
Volume
38
Issue
12
Pages
e21500–e21500
Publication date
15 January 2026
Language
EN