Dendrimers Improve Apolipoprotein Nanoparticle mRNA Delivery to Immune Cells (Adv. Mater. 3/2026)

Advanced Materials 2026 Open access

Read full text
Authors: Mirre M. Trines, Daniek Hoorn, Stijn R. J. Hofstraat, Robby C. Zwolsman, Tom Anbergen, Iris Versteeg, Yuri van Elsas, Jeroen Deckers, M. Hendrikx, Teun Kleuskens, Youssef Bahaaeldin Darwish, Gijs Ros
+13 more Sjoerd F. Dijkstra, Bram Priem, Matt Timmers, P. Michel Fransen, Maarten J. Pouderoijen, Bas F. M. de Waal, Egbert W. Meijer, Thijs J. Beldman, Yohana C. Toner, Ewelina Kluza, Willem J. M. Mulder, Henk M. Janssen, Roy van der Meel
DOI: 10.1002/adma.71895
Cited by: 0

Abstract

mRNA Delivery Apolipoprotein nanoparticles (aNPs) are composed of natural nanomaterials—including phospholipids, sterols, triglycerides, and apolipoprotein A1—and contain rationally designed polyvalent ionizable cationic dendrimers for efficient mRNA complexation. After intravenous administration, aNPs functionally deliver mRNA to myeloid cells in the circulation and their progenitors in the bone marrow. More details can be found in the Research Article by Henk M. Janssen, Roy van der Meel, and co-workers (DOI: 10.1002/adma.202504830).

Fields of Study & Subjects

RNA Interference and Gene Delivery Dendrimers and Hyperbranched Polymers Nanoparticle-Based Drug Delivery

Publication details

Journal / source
Advanced Materials
Volume
38
Issue
3
Publication date
1 January 2026
Language
EN