Polyphenol‐Mediated Engineering of Lipid Nanoparticles With Crystalline Mesophases (Adv. Mater. 6/2026)

Advanced Materials 2026 Open access

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Authors: Shiyao Li, Patrick Charchar, Haitao Yu, Zhixing Lin, Hamish G. Brown, Wanjun Xu, Chan‐Jin Kim, Irene Yarovsky, Yi Ju, Frank Caruso
DOI: 10.1002/adma.72034
Cited by: 0

Abstract

Polyphenol Nanoparticle Engineering On the cover, polyphenol molecules act as dynamic molecular architects, directing lipids to self-assemble into nanostructured lipid nanoparticles with crystalline cubic mesophases. The ordered internal architectures enable the encapsulation of diverse cargos ranging from small molecules and proteins to mRNA. This polyphenol-mediated strategy establishes a versatile and modular platform for advanced therapeutic delivery and architectural nanomaterial design. More details can be found in the Research Article by Yi Ju, Frank Caruso, and co-workers (DOI: 10.1002/adma.202505830).

Fields of Study & Subjects

Nanoparticle-Based Drug Delivery Lipid Membrane Structure and Behavior RNA Interference and Gene Delivery

Publication details

Journal / source
Advanced Materials
Volume
38
Issue
6
Publication date
1 January 2026
Language
EN