Immuno‐Packed T‐Cell‐Fusogenic Liposome Empowers Adoptive T Cell Therapy for Solid Tumor Treatment (Adv. Mater. 8/2026)

Advanced Materials 2026 Open access

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Authors: Chunxiong Zheng, Ke Yi, Yongkang Du, Qingguo Zhong, Huimin KONG, Haixia Wang, Enguo Ju, Yeh‐Hsing Lao, Xi Xie, Haochen Yao, Tao Yu, Yun Liu
DOI: 10.1002/adma.72147
Cited by: 1

Abstract

IMPACTFUL Adoptive T Cell Therapy In their Research Article (DOI: 10.1002/adma.202510842), Mingqiang Li, Yu Tao, Haochen Yao, and co-workers present an immuno-packed T-cell-fusogenic liposome (IMPACTFUL) that enables T-cell engineering through membrane fusion. This approach facilitates concurrent targeting across multiple cellular compartments, including the cell membrane and cytoplasm. By leveraging this dual-targeting strategy, T cells acquire enhanced functionalities, such as improved tumor infiltration, overcoming immune tolerance, and reversing the immunosuppressive tumor microenvironment. This versatile platform offers a promising approach to enhance the therapeutic efficacy of adoptive T cell therapies for solid tumors.

Fields of Study & Subjects

CAR-T cell therapy research Immune Cell Function and Interaction Phagocytosis and Immune Regulation

Publication details

Journal / source
Advanced Materials
Publisher
Wiley
Volume
38
Issue
8
Publication date
1 February 2026
Language
EN