Orally Administered Nanoparticle Coacervate for Therapeutic Coating of Full Gastrointestinal Tract (Adv. Mater. 27/2026)

Advanced Materials 2026

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Authors: Y.Y. Lee, Youngjoon Kim, Seokjun Kwon, Ok Kyu Park, Gyeong Ho Min, Jinyoung Chu, Yubeen Kim, Johyun Yoon, Hyochul Lee, Hojun Kim, Min Soh, Nohyun Lee
+10 more Hojeong Jeon, Yu-Chan Kim, Junchul Kim, Ki Baek Yeo, Seung Hong Choi, Sang Ho Jun, Yuhan Lee, Taeghwan Hyeon, Sang‐Woo Lee, Sang Ihn Han
DOI: 10.1002/adma.73256
Cited by: 1

Abstract

Orally Administered Nanoparticle Coacervate The artwork depicts SHIELD, a sucralfate-derived, paste-like nanoparticle coacervate that forms upon contact with gastrointestinal fluid and advances as a continuous mucosal coating. At inflamed, ulcerated villi, embedded cerium oxide (ceria) nanoparticles catalytically quench excess reactive oxygen species (ROS), creating a transient protective barrier. Behind the advancing front, damaged mucosa transitions toward restored architecture. More details can be found in the Research Article by Taeghwan Hyeon, Sang-woo Lee, Sang Ihn Han, and co-workers (DOI: 10.1002/adma.202514708).

Fields of Study & Subjects

Advanced Drug Delivery Systems Surgical Sutures and Adhesives Drug Solubulity and Delivery Systems

Publication details

Journal / source
Advanced Materials
Publisher
Wiley
Volume
38
Issue
27
Publication date
1 May 2026
Language
EN