High‐Efficiency Targeted Mitochondrial Transfer and AUTAC4‐Enhanced Dual Renewal Strategy for Rheumatoid Arthritis (Adv. Mater. 32/2026)

Advanced Materials 2026

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Authors: Fuxiao Wang, H W Zhang, Dongyang Zhou, Xuan Tang, Yi-Xiang Wang, H Liu, X Y Wang, Yuanwei Zhang, Z L Li, Y Jiang, Qin Zhang, Xiao Chen
+5 more Yingying Jing, Ke Xu, Yun Hu, Lu Bai, Jiacan Su
DOI: 10.1002/adma.73488
Cited by: 1

Abstract

Dual Renewal Strategy for Rheumatoid Arthritis Inspired by Chinese philosophy, this cover illustrates a dual-action mitochondrial renewal therapy (DAMRT) for rheumatoid arthritis. Like a lotus leaf, a folate-modified macrophage membrane precisely encapsulates healthy mitochondria and AUTAC4. This biomimetic system targets inflamed joints, delivering fresh mitochondria while degrading dysfunctional ones to effectively restore cellular metabolic homeostasis. More details can be found in the Research Article by Ke Xu, Yan Hu, Long Bai, Jiacan Su, and co-workers (DOI: 10.1002/adma.202514070).

Fields of Study & Subjects

Protein Degradation and Inhibitors Immune cells in cancer Nanoplatforms for cancer theranostics

Publication details

Journal / source
Advanced Materials
Publisher
Wiley
Volume
38
Issue
32
Publication date
1 June 2026
Language
EN