Antioxidant Proline Carbon Dot‐Composited Poly(L‐methionine) Hydrogel Restores Mitophagy to Alleviate Cellular Senescence in Intervertebral Disc Degeneration (Adv. Mater. 46/2026)

Advanced Materials 2026

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Authors: Zongtai Liu, Qingzheng Zhang, Haochen Yao, Changfeng Fu, Yirong Sun, Jianxun Ding
DOI: 10.1002/adma.74557
Cited by: 1

Abstract

Proline Carbon Dot Hydrogel Restores Disc Mitophagy The artwork shows a proline carbon dot-composite hydrogel counteracting oxidative stress-induced senescence of nucleus pulposus cells in intervertebral disc degeneration. It rescues defective mitophagy, rebalances mitochondrial redox, and revives energy metabolism. Like an explorer uncovering buried treasure, damaged mitochondria in degenerated discs are restored to radiant forms, leading to recovered disc height and matrix proteins, symbolizing disc rejuvenation. More details can be found in the Research Article by Jianxun Ding, Yirong Sun, Changfeng Fu, Haochen Yao, and co-workers (DOI: 10.1002/adma.72951).

Fields of Study & Subjects

Spine and Intervertebral Disc Pathology Carbon and Quantum Dots Applications Graphene and Nanomaterials Applications

Publication details

Journal / source
Advanced Materials
Publisher
Wiley
Volume
38
Issue
46
Publication date
1 August 2026
Language
EN