Flexible Implantable Silicon Carbide Multi‐Electrode Array (MEA) for Cell Multichannel Recording and Cell Ablation

ABSTRACT Cancer incidence continues to rise globally, highlighting an urgent need for advanced bioelectronic technologies capable of simultaneous cellular monitoring and highly localized therapeutic intervention. In this work, we present a flexible implantable silicon carbide (SiC) multi‐electrode array (MEA) designed for multichannel electrophysiological recording and targeted irreversible electroporation (IRE)‐based cancer cell ablation. Leveraging the wide‐bandgap properties, chemical inertness, mechanical robustness, and proven biocompatibility of SiC, the proposed MEA provides a durable and reliable platform for long‐term operation under physiological conditions. Electrical characterization demonstrates excellent signal fidelity, with near‐unity transmission efficiency and minimal signal distortion maintained across frequencies from 0.1 to 100 Hz, even after 2000 bending cycles. In vitro experiments show that the SiC MEA enables stable, simultaneous multichannel recording of MDA‐MB‐231 breast cancer cells, capturing enhanced current fluctuations associated with cellular attachment and metabolic activity. Furthermore, the device successfully induces localized IRE, leading to effective cancer cell ablation without reliance on thermal mechanisms. In vivo implantation studies confirm favorable biocompatibility, with no significant inflammation, fibrosis, or adverse tissue responses observed. Collectively, these results establish flexible SiC‐based MEAs as a platform for precision‐targeted cancer treatment and monitoring.