Enantioselective α‐Aminoxylation of Ketones Catalyzed by a Chiral Brønsted Acid
Abstract
Development of new asymmetric radical reactions is of significant interest to the synthetic community. In this article, we describe a chiral Brønsted acid catalyzed enantioselective α‐oxidation of ketones carrying heteroaromatic templates using TEMPO and a metal oxidant. The methodology provides access to α‐aminoxylated ketones in high yields and good enantioselectivities.
Fields of Study & Subjects
Asymmetric Synthesis and Catalysis
Oxidative Organic Chemistry Reactions
Metal-Catalyzed Oxygenation Mechanisms
Publication details
- Journal / source
- Advanced Synthesis & Catalysis
- Volume
- 368
- Issue
- 3
- Publication date
- 3 February 2026
- Language
- EN