B(C 6 F 5 ) 3 ‐Catalyzed Cross‐Dehydrogenative Coupling of Arenes and Phosphites With Tetrahydroisoquinolines

Advanced Synthesis & Catalysis 2026 Open access

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Authors: Riya Rakheja, Swagata Maity, Pragya Sharma, Chinmoy Kumar Hazra
DOI: 10.1002/adsc.70288
Cited by: 1
References: 50

Abstract

Cross‐dehydrogenative coupling (CDC) reactions have emerged as a powerful strategy for direct CH functionalization, yet many approaches rely on harsh oxidants, light‐driven processes, or expensive electrochemical setups, which limit their applicability. Here, we report a B(C 6 F 5 ) 3 ‐catalyzed approach that enables efficient α‐hydride abstraction of N ‐aryl tetrahydroisoquinolines under mild conditions. Mechanistic studies suggest that the reaction proceeds through the formation of an iminium ion. Overall, this work establishes a practical and sustainable approach to CDC reactions, highlighting the potential of B(C 6 F 5 ) 3 catalysis for direct CH functionalization.

Fields of Study & Subjects

Organoboron and organosilicon chemistry Catalytic C–H Functionalization Methods Radical Photochemical Reactions

Publication details

Journal / source
Advanced Synthesis & Catalysis
Publisher
Wiley
Volume
368
Issue
3
Publication date
2 February 2026
Language
EN