Photoredox‐Catalyzed Chlorosulfonylation of gem ‐Difluoroalkenes
Abstract
A visible‐light‐catalyzed chlorosulfonylation reaction of gem ‐difluoroalkenes has been successfully developed using sulfonyl chloride as both the sulfonyl group and chlorine source. The reaction proceeds under mild, additive‐free conditions, generating α , α ‐difluoromethyl‐ β ‐chlorosulfones with excellent regioselectivity and broad substrate scope. The β ‐chlorosulfone product serves as versatile intermediate, readily converting into valuable derivatives such as β ‐azido sulfone. This method provides rapid access to functional fluorinated scaffolds relevant to medicinal chemistry.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Sulfur-Based Synthesis Techniques
Radical Photochemical Reactions
Publication details
- Journal / source
- Advanced Synthesis & Catalysis
- Publisher
- Wiley
- Volume
- 368
- Issue
- 4
- Publication date
- 15 February 2026
- Language
- EN