PhICl 2 /KSeCN‐Mediated Cascade Synthesis of 3,3′‐Diindolyl Selenides From 2‐Alkynylanilines
Abstract
The reaction of 2‐alkynylanilines with KSeCN enabled by PhICl 2 in anhydrous MeCN was found to undergo an alternative pathway distinct from the previous report, furnishing 3,3′‐diindolyl selenides in moderate to good yield. The mechanistic studies support a cascade process involving the formation of the electrophilic selenocyanogen chloride from the reaction of PhICl 2 and KSeCN, electrophilic cyclization/selenocyanation of 2‐alkynylanilines to forge 3‐selenocyanato indole nuclei, followed by its further reaction with 2‐alkynylanilines to give the title 3,3′‐diindolyl selenides.
Fields of Study & Subjects
Organoselenium and organotellurium chemistry
Catalytic Alkyne Reactions
Synthesis and Characterization of Pyrroles
Publication details
- Journal / source
- Advanced Synthesis & Catalysis
- Publisher
- Wiley
- Volume
- 368
- Issue
- 7
- Publication date
- 27 March 2026
- Language
- EN