Mechanochemical Synthesis of N, N‐Disubstituted 2‐Amino‐Thiazolines, and 1,3‐Thiazolidine‐2‐Imine Hydrochlorides
Abstract
The mechanochemical synthesis of 4,5‐dihydro‐1,3‐thiazol‐2‐amines and 1,3‐thiazolidine‐2‐imine hydrochlorides has been performed starting from chloroalkyl isothiocyanate and amines in the presence of potassium carbonate. The proposed procedure is efficient under transition metal‐ and solvent‐free ball‐milling conditions with the use of a mixer mill. The reactions are selective and show no significant decrease in yields across a broad scope of substrates bearing different functional groups. Moreover, the successful 1 g scale‐up experiment demonstrates the practical applicability of the method.
Fields of Study & Subjects
Synthesis and Reactivity of Sulfur-Containing Compounds
Synthesis of heterocyclic compounds
Multicomponent Synthesis of Heterocycles
Publication details
- Journal / source
- Advanced Synthesis & Catalysis
- Volume
- 368
- Issue
- 6
- Publication date
- 4 March 2026
- Language
- EN