Advances in the Synthesis of Levetiracetam: Classical Approaches and Patented Innovations

Advanced Synthesis & Catalysis 2026

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Authors: Murugesan Sivaprakash, Kothapalli Bannoth Tejaswini, Kiran Kumar Pulukuri, Purushothaman Gopinath, Ekambaram Balaraman
DOI: 10.1002/adsc.70358
Cited by: 3
References: 38

Abstract

Levetiracetam, a widely used antiepileptic drug, is notable for its unique mechanism and favorable safety profile. This review summarizes the evolution of its synthesis, from early methods to recent innovations aimed at improving yield, cost‐efficiency, and environmental impact. Key publications and patents are discussed, highlighting industrial advancements and research progress. The article serves as a valuable resource for professionals in pharmaceutical synthesis and explores future directions in levetiracetam production and related compounds.

Fields of Study & Subjects

Pharmacological Receptor Mechanisms and Effects Chemical Reactions and Isotopes Synthesis and pharmacology of benzodiazepine derivatives

Publication details

Journal / source
Advanced Synthesis & Catalysis
Publisher
Wiley
Volume
368
Issue
7
Publication date
26 March 2026
Language
EN