Enantioselective Synthesis of Triarylmethanes Containing Three Different Aryl/Heteroaryl Moieties by Chiral Phosphoric Acids Catalyzed Friedel−Crafts Reactions
Abstract
An efficient catalytic enantioselective Friedel–Crafts reaction of indoles with in situ‐generated 3‐methide‐3 H ‐pyrroles from pyrrole‐3‐carbinols by a chiral phosphoric acid is developed. A large variety of triarylmethanes bearing two different heteroaryl groups (indole and pyrrole) and a phenyl group are achieved in 14%–98% yields with up to 96% ee. Notably, previously unreported triarylmethanes incorporating three distinct heteroaryl moieties are successfully synthesized using this strategy. This synthetic strategy provides a straightforward and versatile approach to enantioenriched triarylmethanes with structural diversity.
Fields of Study & Subjects
Synthesis of Indole Derivatives
Multicomponent Synthesis of Heterocycles
Synthesis and pharmacology of benzodiazepine derivatives
Publication details
- Journal / source
- Advanced Synthesis & Catalysis
- Publisher
- Wiley
- Volume
- 368
- Issue
- 6
- Publication date
- 12 March 2026
- Language
- EN