Cover Feature: Engineering Cumene Dioxygenase for Regioselective Hydroxylation of Monoterpenes and Monoterpenoids (Adv. Synth. Catal. 4/2026)

Advanced Synthesis & Catalysis 2026

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Authors: Jona T. Schelle, Julian L. Wissner, Isabell Muth, Carla Calvó‐Tusell, Jonathan B. Berger, Marc Garcia‐Borràs, Gloria Saab‐Rincón, Bernhard Hauer
DOI: 10.1002/adsc.70368
Cited by: 0

Abstract

Engineering Cumene Dioxygenase The painted design by Fátima Navarro-Cetina and WesWizzArt depicts the cumene dioxygenase-catalyzed hydroxylation of monoterpenes. Engineering of this enzyme (depicted as a figurine) yielded variants exhibiting exceptional regioselective control and product formation across various monoterpenes and monoterpenoids, including α-pinene and limonene (stylized as the stems of pine and lemon trees), producing highly sought-after fragrance compounds (depicted in the branches of the corresponding trees). More information can be found in the Research Article by Bernhard Hauer and co-workers (10.1002/adsc.70323).

Fields of Study & Subjects

Enzyme Catalysis and Immobilization Metal-Catalyzed Oxygenation Mechanisms Biochemical and biochemical processes

Publication details

Journal / source
Advanced Synthesis & Catalysis
Volume
368
Issue
4
Publication date
15 February 2026
Language
EN