Electro‐Redox‐Mediated Formal (3+2) Cycloaddition: Sustainable Synthesis of Tetrazoloquinoxalinones
Abstract
A sustainable electrochemical protocol for the synthesis of tetrazolo[1,5‐ a ]quinoxalin‐4(5 H )‐one is developed. The notable feature of this method is the application of an electro‐redox mediator 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ), which empowered the use of sodium azide as an economical azide source. The developed formal (3 + 2) cycloaddition strategy affords a broad range of functionalized tetrazoloquinoxalinone derivatives with potential biological relevance. Detailed synthetic and electrochemical studies elucidated the mediator‐assisted electrocatalytic mechanism, highlighting the advantages of this transition metal‐free electrochemical approach.
Fields of Study & Subjects
Radical Photochemical Reactions
Synthesis of Tetrazole Derivatives
Quinazolinone synthesis and applications
Publication details
- Journal / source
- Advanced Synthesis & Catalysis
- Publisher
- Wiley
- Volume
- 368
- Issue
- 7
- Publication date
- 31 March 2026
- Language
- EN