Facile Access to N ‐Substituted Pyridyl Ligands

Advanced Synthesis & Catalysis 2026 Open access

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Authors: Adam Petrik, Aleksander R. Bena, Haralds Baunis, Riley M. Kelch, Tehshik P. Yoon, Bartholomäus Pieber
DOI: 10.1002/adsc.70417
Cited by: 1
References: 39

Abstract

Pyridyl motifs equipped with N ‐substituents can be powerful ligands for catalysis, yet their broader adoption is limited by the lack of a practical method to prepare these scaffolds. We report a modular, robust, and versatile Buchwald–Hartwig amination protocol that enables the rapid synthesis of bipyridine, phenanthroline, terpyridine, and pybox ligands bearing dialkylamine, diarylamine, and heteroaromatic N ‐substituents. These conditions streamline ligand library synthesis and will facilitate systematic studies in catalysis and related applications.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Catalytic C–H Functionalization Methods N-Heterocyclic Carbenes in Organic and Inorganic Chemistry

Publication details

Journal / source
Advanced Synthesis & Catalysis
Publisher
Wiley
Volume
368
Issue
9
Publication date
23 April 2026
Language
EN