Sono‐Photoinduced Self‐Catalyzed Acyloxylation of 4H‐Pyrido[1,2‐a]Pyrimidin‐4‐Ones with Aryl Diacyl Peroxides and Bioactivities of Products
Abstract
A novel self‐catalyzed sono‐photoinduced C–H acyloxylation of 4H‐pyrido[1,2‐a]pyrimidin‐4‐ones with aryl diacyl peroxides has been established. This protocol employs eco‐friendly DMC as the solvent and proceeds efficiently without exogenous catalysts or additives, affording C3‐acyloxylated derivatives in good to excellent yields. The synergistic sono‐photocatalysis strategy significantly enhances reaction kinetics, product yields, and energy efficiency compared to traditional photocatalytic methods. Moreover, preliminary biological assays reveal that the synthesized compounds exhibit promising antitumor activities.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Oxidative Organic Chemistry Reactions
Publication details
- Journal / source
- Advanced Synthesis & Catalysis
- Publisher
- Wiley
- Volume
- 368
- Issue
- 9
- Publication date
- 20 April 2026
- Language
- EN