Deconstructive Alkynylation of Spiro‐Dihydroquinazolinones via Aromatization‐Driven Ring Opening Under Visible Light Irradiation

Advanced Synthesis & Catalysis 2026

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Authors: Dharavath Ravi, Vadithya Ranga Rao, Vadla Shiva Prasad, Silari MohanaKrishna, Madasu Gangaraju, Chelukalapally Anil Kumar, Praveen Reddy Adiyala
DOI: 10.1002/adsc.70428
Cited by: 1
References: 81

Abstract

Here, we report a visible light‐driven, metal‐free photoredox strategy enabling the deconstructive C(sp 3 )–C(sp) coupling of spiro‐dihydroquinazolinones with alkynyl sulfones, providing efficient access to structurally diverse alkynylated quinazolinone scaffolds via an aromatization‐induced radical pathway under mild conditions. Furthermore, translation of the batch protocol to a PFA‐based continuous‐flow reactor enhances reaction efficiency, shortens reaction time, and demonstrates its practical scalability. Mechanistic studies supports the involvement of a radical mediated transformation.

Fields of Study & Subjects

Radical Photochemical Reactions Innovative Microfluidic and Catalytic Techniques Innovation Click Chemistry and Applications

Publication details

Journal / source
Advanced Synthesis & Catalysis
Publisher
Wiley
Volume
368
Issue
9
Publication date
20 April 2026
Language
EN