Base‐Promoted Multicomponent Reaction of Phthalaldehyde With Amines and Sulfur: Access to 3‐Iminoisoindoline‐1‐Thiones

Advanced Synthesis & Catalysis 2026

View at publisher
Authors: Le Anh Nguyen, Quoc Anh Ngo, Dinh Hung Mac, Thi Thu Tram Nguyen, Thi Thu Tram Nguyen, Pascal Retailleau, T D K Nguyen, T D K Nguyen
DOI: 10.1002/adsc.70435
Cited by: 1
References: 29

Abstract

A base‐catalyzed, oxidative multicomponent condensation involving primary anilines, elemental sulfur, and phthalaldehyde is reported. Utilizing readily available starting materials, this protocol affords a novel series of structurally diverse 3‐iminoisoindoline‐1‐thiones in satisfactory yields under mild reaction conditions. Furthermore, the methodology was successfully extended to 1,8‐diaminonaphthalene, yielding the photosensitizer 12 H ‐isoindolo[2,1‐ a ]perimidine‐12‐thione in excellent yields with a simplified purification process via filtration.

Fields of Study & Subjects

Multicomponent Synthesis of Heterocycles Synthesis and pharmacology of benzodiazepine derivatives Quinazolinone synthesis and applications

Publication details

Journal / source
Advanced Synthesis & Catalysis
Publisher
Wiley
Volume
368
Issue
9
Publication date
23 April 2026
Language
EN