Strategic Functionalization of Benzylic C(sp 3 )H Bonds: Unlocking the Potential for Enantioselective δ ‐Lactonization
Abstract
Recent advancements in bio‐inspired Mn‐catalyzed directed oxidations of carboxylic acids have provided promising pathways for the synthesis of a wide variety of chiral γ ‐lactones. In our current study, however, we have established a catalytic route using 0.25 mol% of electron‐rich Mn‐catalyst Mn( dMM bpbp) that redirects the lactonization reaction to the δ ‐position, with high enantiomeric excess (over 80%). To the best of our knowledge, selective oxidative δ ‐lactonizations in an enantioselective pathway have not been reported earlier using a transition metal‐catalyzed manner. Our methodology can be extended to the enantioselective synthesis of benzo‐fused δ ‐lactones (up to 70% yield and 62% ee).
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Cyclopropane Reaction Mechanisms
Metal-Catalyzed Oxygenation Mechanisms
Publication details
- Journal / source
- Advanced Synthesis & Catalysis
- Publisher
- Wiley
- Volume
- 368
- Issue
- 9
- Publication date
- 5 May 2026
- Language
- EN