NaIO 4 ‐Promoted Selenylation/Cyclization Reactions of 1‐(2‐(Vinyloxy)aryl)‐Indoles to Assemble Selenized Benzo[5,6][1,4]oxazino[4,3‐ a ]indole Derivatives
Abstract
The NaIO 4 ‐promoted selenylation/cyclization of 1‐(2‐(vinyloxy)aryl)‐indoles with diselenides has been reported for the synthesis of selenized benzo[5,6][1,4]oxazino[4,3‐ a ]indole derivatives. In this synthesis, the indole moiety with significant medicinal value, the morpholine skeleton, and the selenium group were introduced into a privileged structure, resulting in the target compound with potential value. The reaction features wide substrate scope, high group tolerance and good yield, which also represents the first selenylation/cyclization of 1‐(2‐(vinyloxy)aryl)‐indoles and diselenides.
Fields of Study & Subjects
Organoselenium and organotellurium chemistry
Sulfur-Based Synthesis Techniques
Catalytic Alkyne Reactions
Publication details
- Journal / source
- Advanced Synthesis & Catalysis
- Publisher
- Wiley
- Volume
- 368
- Issue
- 9
- Publication date
- 1 May 2026
- Language
- EN