Enaminone Triggered Ring Opening of Cyclopropenones for Enamide Synthesis and Its Application in Oxazole Construction

Advanced Synthesis & Catalysis 2026

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Authors: Xinyuan Wen, Changfeng Wan, Jie‐Ping Wan, Yunyun Liu
DOI: 10.1002/adsc.70534
Cited by: 1
References: 67

Abstract

Herein, we report an addition‐elimination ring opening reaction cascade between cyclopropenones and enaminones with Ag(I) catalysis. The successful utilization of enaminones as the carbon nucleophiles enables the practical synthesis of enamides via ring opening. In addition, the two‐step operation by subjecting the in situ generated enamides to oxidative conditions allows the synthesis of oxazoles featuring a C2‐vinyl substituent by CO bond construction.

Fields of Study & Subjects

Synthesis and Characterization of Pyrroles Synthesis and Reactivity of Heterocycles Catalytic C–H Functionalization Methods

Publication details

Journal / source
Advanced Synthesis & Catalysis
Publisher
Wiley
Volume
368
Issue
11
Publication date
1 June 2026
Language
EN