Mechanically Assisted PO, PN, and PS Bonds Formation

Advanced Synthesis & Catalysis 2026 Open access

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Authors: Camilo Morales-Manrique, Mónica Rey‐Montaño, Daniela Torres-Ruiz, Carlos Bermudez‐Gonzalez, Diego Gamba‐Sánchez
DOI: 10.1002/adsc.70568
Cited by: 1
References: 39

Abstract

We report a general and efficient mechanochemical protocol for the formation of PO, PN, and PS bonds through the reaction of phosphoryl chlorides with O‐, N‐, and S‐centered nucleophiles. The transformation proceeds under solvent‐free conditions using ball milling in the presence of triethylamine and an inert grinding auxiliary, under ambient atmosphere and short reaction times. A broad range of primary and secondary alcohols, phenols, amines, anilines, and thiols are compatible with the methodology, affording the corresponding phosphates, phosphoramidates, and thiophosphates in moderate‐to‐excellent yields.

Fields of Study & Subjects

Organophosphorus compounds synthesis Crystallography and molecular interactions Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Advanced Synthesis & Catalysis
Publisher
Wiley
Volume
368
Issue
11
Publication date
28 May 2026
Language
EN