Copper‐Catalyzed Three‐Component Cascade Reaction of Azomethine Imines, Alkynes, and Diselenides

Advanced Synthesis & Catalysis 2026

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Authors: Wei Jiang, Z L Yang, Cui Zhang, Tai‐Gang Fan, M Wang, Yi Li, Ya‐Min Li
DOI: 10.1002/adsc.70632
Cited by: 1
References: 64

Abstract

A copper‐catalyzed three‐component cascade reaction of azomethine imines, alkynes, and diselenides has been developed for the synthesis of selenated N , N′ ‐bicyclic pyrazolines. This protocol integrates selenation with 1,3‐dipolar cycloaddition in a one‐pot reaction, featuring a broad substrate scope, excellent regioselectivity, and high atomic economy. Mechanistic studies indicate that the reaction proceeds via two pathways: 1,3‐dipolar cycloaddition of selenoalkynes with azomethine imines and selenation of cuprate‐pyrazoline.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Organoselenium and organotellurium chemistry Click Chemistry and Applications

Publication details

Journal / source
Advanced Synthesis & Catalysis
Publisher
Wiley
Volume
368
Issue
14
Publication date
9 July 2026
Language
EN